The Supreme Court on Thursday rejected a controversial settlement that would have sent billions of dollars to treatment programs and victims of the nation’s opioid epidemic but that also shielded the Sackler family from future lawsuits despite the fact that it made its fortune selling prescription opioids.
Kavanaugh said in dissent that the court’s decision will have a “devastating” impact on thousands of victims of the opioid epidemic.
"As a result, opioid victims are now deprived of the substantial monetary recovery that they long fought for and finally secured after years of litigation,” he wrote in the dissent, which was joined by Chief Justice John Roberts and liberal Justices Sonia Sotomayor and Elena Kagan.
It’s important to note that in historical examples of these settlements, the money was us d as a slush fund.
When tobacco did their settlement, it was used for stuff like schools and toads, then taxes were cut instead. Resulting in no increase in funding then when the settlement money ran out, they were broke. In some cases the settlement money was even used to pay for tobacco infrastructure (auction houses and such).
Can’t remember if it was Oliver or Stewart, but one of them did a show/segment on it recently.
And that’s not even getting into the settlement didn’t touch any of the Sacker money directly.
And the company 100% knew that extended release wouldn’t work the same on everyone, some people would be pretty much guaranteed to become addicts if they followed their prescriptions. They’d just naturally metabolize it too fast.
But they made more money. So they pushed XR to doctors and patients while hiding the fact that it was dangerous.
They need to be in jail, which won’t happen. But we can at least fuck their personal blood money up.
I’m very surprised the pharmaceutical market hasn’t produced the opioid analogue to Vyvanse requiring enzymatic conversion as opposed to mechanical release -> long lasting natural extended release mechanism. Its a great idea that hasn’t seemed to expand to many other therapeutic agents
I don’t know vyvanse xr method of action off the top of my head…
But for opioids the difference in in enzymatic breakdown is already problematic.
Even for non XR, some people just burn thru it at different rates.
Personally I don’t have enough of a couple of the L enzymes and that means most opioids barely do anything to me. Some people have too much and will burn thru a Vicodin in half as much time, leaving them unmedicated for half the time.
There’s just too much human variation for a one sized fits all approach.
The point I’m making is, while I’m aware of people being fast or slow metabolizers, that should only factor in when it comes to active ingredient that is fully mechanically released and available for metabolism.
It cannot metabolize that which has not either been a) mechanically released or b) that which is pharmacodynamically inertt since it requires cleaving off the other binding substance (like l-lysine in Vyvanse) before the underlying active drug can be mechanically available to metabolize if that makes sense.
Vyvanse cannot be injected or administered in basically any other ROA than oral like normal dex because it (lis-dexamferamine—not dextroamphetamine) is inert until it has undergone the uncleaving of lysine from the active drug. Doesn’t matter how fast one metabolizes dextro, nobody metabolizes lis as a straight stimulant, it is inert until made not so thru the blood or whatever.
Also, doesn’t that mostly apply to codeine and morphine, wasn’t aware of that extending to oxy and hydro?
I think there is likely to still be just as large of a personal variance in the rate that lisdexamphetamine is cleaved into the active metabolite, so the same problem arises.
I think anything that delays the active metabolite from taking effect technically dampens the addictive potential; the longer the better. I also think it’s unlikely to really solve the problem though tbh. People can still tell what’s causing how they feel when they start a new medication.
You’re never gonna fully attnuate all the edge cases and it doesn’t really matter that some people end up being “allergic” or oversensitive or undersensitive to it. Thats what titration and medical supervision are for, not everything works for everyone.
Thats why choice and second/third/fourth line etc treatments exist. I sometimes do wonder if you did a double blind with folks and didn’t tell them, I would conjecture the hyper-extended nature of such things if that were so established could be sufficient to mitigate for individual differences in metabolic-polymorphism or whatever
It’s important to note that in historical examples of these settlements, the money was us d as a slush fund.
When tobacco did their settlement, it was used for stuff like schools and toads, then taxes were cut instead. Resulting in no increase in funding then when the settlement money ran out, they were broke. In some cases the settlement money was even used to pay for tobacco infrastructure (auction houses and such).
Can’t remember if it was Oliver or Stewart, but one of them did a show/segment on it recently.
And that’s not even getting into the settlement didn’t touch any of the Sacker money directly.
And the company 100% knew that extended release wouldn’t work the same on everyone, some people would be pretty much guaranteed to become addicts if they followed their prescriptions. They’d just naturally metabolize it too fast.
But they made more money. So they pushed XR to doctors and patients while hiding the fact that it was dangerous.
They need to be in jail, which won’t happen. But we can at least fuck their personal blood money up.
NOW WE ARE TALKING
Mullah Kavanaugh’s logic has no merit, he knows it and anyone with half a brain also knows this.
The whole write was the news headlines to make majority seem like the assholes… pathetic Mullah Kavanaugh
But why are the liberal justices falling for it?
Mullahs are not liberal in any sense of the word lol
Kagan, Jackson, Sotomayor are usually referred to as the liberal justices, aren’t they? Not sure whatchu getting at?
Also, why are you referring to them as Mullahs, they’re not religious teachers, any of them
labeling as them as liberal makes them seem like they are on “liberal” team whatever that means.
Mullahs are the owner class team.
Do you honestly believe folks like Jackson are equivalent to people like Thomas/Alito beyond their legal pedigree? You think she wants what they do?
i think peasants’ worship of the mullahs is a futile exercise similar to watching young bucks in tights throwing a pig skin around.
I was always more a LeBron guy myself tho!
I don’t worship them I simply get surprised time to time altho maybe I should read their full dissents to get a better idea
That sound everyone just heard was the Overton window flying by…
We have far right fascists justices and pro corporation “moderate” justices.
Neither are going to pick people over corporations often when it matters.
It was Oliver.
I’m very surprised the pharmaceutical market hasn’t produced the opioid analogue to Vyvanse requiring enzymatic conversion as opposed to mechanical release -> long lasting natural extended release mechanism. Its a great idea that hasn’t seemed to expand to many other therapeutic agents
I don’t know vyvanse xr method of action off the top of my head…
But for opioids the difference in in enzymatic breakdown is already problematic.
Even for non XR, some people just burn thru it at different rates.
Personally I don’t have enough of a couple of the L enzymes and that means most opioids barely do anything to me. Some people have too much and will burn thru a Vicodin in half as much time, leaving them unmedicated for half the time.
There’s just too much human variation for a one sized fits all approach.
The point I’m making is, while I’m aware of people being fast or slow metabolizers, that should only factor in when it comes to active ingredient that is fully mechanically released and available for metabolism.
It cannot metabolize that which has not either been a) mechanically released or b) that which is pharmacodynamically inertt since it requires cleaving off the other binding substance (like l-lysine in Vyvanse) before the underlying active drug can be mechanically available to metabolize if that makes sense.
Vyvanse cannot be injected or administered in basically any other ROA than oral like normal dex because it (lis-dexamferamine—not dextroamphetamine) is inert until it has undergone the uncleaving of lysine from the active drug. Doesn’t matter how fast one metabolizes dextro, nobody metabolizes lis as a straight stimulant, it is inert until made not so thru the blood or whatever.
Also, doesn’t that mostly apply to codeine and morphine, wasn’t aware of that extending to oxy and hydro?
I think there is likely to still be just as large of a personal variance in the rate that lisdexamphetamine is cleaved into the active metabolite, so the same problem arises.
I think anything that delays the active metabolite from taking effect technically dampens the addictive potential; the longer the better. I also think it’s unlikely to really solve the problem though tbh. People can still tell what’s causing how they feel when they start a new medication.
You’re never gonna fully attnuate all the edge cases and it doesn’t really matter that some people end up being “allergic” or oversensitive or undersensitive to it. Thats what titration and medical supervision are for, not everything works for everyone.
Thats why choice and second/third/fourth line etc treatments exist. I sometimes do wonder if you did a double blind with folks and didn’t tell them, I would conjecture the hyper-extended nature of such things if that were so established could be sufficient to mitigate for individual differences in metabolic-polymorphism or whatever
Morphine (not sure about codeine) are/is one of the few options that are direct acting.
Oxy, Vicodin, and all the rest first get broken down I to an active metobalite. Even if they’re not XR. XR just compounds the issue